After redshirting his freshman season,[1] Grant was named to the Big East Conference All-Rookie team after averaging 12.3 points and 4.97 assists per game.

[2] In his second season with the Irish, Grant was named second-team All-Big East after averaging 13.3 points and 5.5 assists per game.

But on December 23, 2013, Grant was ruled academically ineligible for the rest of the season and forced to withdraw from Notre Dame.

[8][9] The Grant-led Irish finished the year with a 32–6 record and an ACC Tournament championship; they advanced to the Elite 8 in the Midwest Region, where they lost to an undefeated Kentucky team by 2 points.

[15] On June 22, 2016, Grant was traded, along with José Calderón and Robin Lopez, to the Chicago Bulls in exchange for Derrick Rose, future teammate Justin Holiday and a 2017 second-round draft pick.

[16] The following month, he helped the Bulls win the Las Vegas Summer League championship game and earned MVP honors for his 24 points, 10 rebounds, and five assists.

[27] On June 30, 2019, Grant did not receive a qualifying offer from the Magic, making him an unrestricted free agent.

On July 1, 2021, Grant officially signed a two-year deal with Olimpia Milano of the Lega Basket Serie A and the EuroLeague, under coach Ettore Messina.

[36] In the domestic league, he averaged 16.4 points, 3.6 rebounds and 5.7 assists per game, leading the club to the 1st place in the regular season standings.

His uncle and father's identical twin Horace Grant was an NBA All-Star and won four championships with the Chicago Bulls and Los Angeles Lakers.