Jersey Mills is an unincorporated community in McHenry Township, Lycoming County, in the U.S. state of Pennsylvania.

Callahan Run enters Pine Creek at Jersey Mills.

[3] The first white settlers in the vicinity of what became Jersey Mills arrived in the late 18th and very early 19th centuries.

The village of Jersey Mills was officially established in 1855, when its post office opened.

A smaller general store, the last commercial business in Jersey Mills, operated from 1980 though 2007.