Slate Run is an unincorporated community in Brown Township, Lycoming County, in the U.S. state of Pennsylvania.

[3] Pioneer settler Jacob Tomb and his family established a home, sawmill, and gristmill at the mouth of Slate Run in the 1790s, and others settled nearby along the Pine Creek floodplain.

[4] Driving the local economy toward the end of the century was the James B. Weed and Company hemlock sawmill, which operated in Slate Run from 1886 to 1910 and produced up to 100,000 board feet of lumber a day.

After the end of the lumber era, the mill closed, and the village declined in size.

However, in the early 21st century, Slate Run still has a general store and post office, and a hotel with a restaurant and bar.