Born in São Paulo, Jesiel started his youth career with the academy of Red Bull Brasil and moved to Atlético Mineiro in 2012.

[2][1] On 7 February 2016, Jesiel made his first team debut, starting in a 2–1 defeat against Figueirense, in Primeira Liga.

[3] To get more playing time and first team experience, he joined Série B side Bragantino on loan on 16 February.

[10] On 31 December 2018, Jesiel moved to Japanese J1 League side Kawasaki Frontale ahead of the 2019 season, joining on loan until 1 January 2020.

For 2023 season, along with the appointment of Kento Tachibanada as the new club captain of Frontale, Jesiel became one of three players selected as the vice-captains alongside Kyohei Noborizato and Yasuto Wakizaka.