Outside of repertory theatres, Dwyre has acted at Soulpepper (Great Expectations, Farther West),[1] the Segal Centre for Performing Arts as Ken in Red (play) directed by Martha Henry.

In classic novels adapted to the stage, Dwyre has played Bernard Marx in Aldous Huxley's Brave New World at Theatre Passe Muraille.

Dwyre was the first actor to portray Shade, the lead role in the premiere of Silverwing by Kenneth Oppel at Manitoba Theatre for Young People in Winnipeg.

Adam's Wall is a tale of forbidden love between a Jewish boy and a Lebanese girl directed by Michael Mackenzie and produced by Ziad Touma of Couzin Films.

[4] In The Archivist Dwyre plays Cedric, an assistant projectionist at an aging movie theatre who risks confrontation with his supervisor when he investigates a series of mysterious disappearances.

Dwyre has also appeared in short films: Dangerous Heroes by Svjetlana Jaklenec, The Cats by Hakan Oztan, The Fursteneau Mysteries by Illya Klymkiw.

Dwyre has also played Romeo in Bravo's Shakespeare in Words and Music, NBC's 10.5: Apocalypse, Cine Qua Non's Mary Shelley, CBS's Beauty & the Beast and Clementine, and CBC's The Fifth Estate among others.

[citation needed] Jesse Aaron Joseph Dwyre was born in Kingston and grew up in the small mill town of Lyndhurst, Ontario.