Jesse Lawrence Barnes (August 26, 1892 – September 9, 1961) was an American pitcher in Major League Baseball.

On the last day of the 1919 season, Barnes won his National League-leading 25th victory, 6–1, over Lee Meadows and the Philadelphia Phillies at Polo Grounds.

Then, on May 7, 1922, he hurled a no-hitter against the Phillies; Cy Williams was the only baserunner, who walked and was erased on a double play.

Barnes returned to the Braves in 1923, playing for them three years before joining the Brooklyn Robins during 1926 and 1927.

The baseball author and analyst Bill James is also a distant relative of the brothers.