Jesse Alan Crain (born July 5, 1981) is a Canadian former professional baseball pitcher.

He played in Major League Baseball (MLB) for the Minnesota Twins and Chicago White Sox.

Crain was born in Toronto, Ontario and attended Fairview High School in Boulder, Colorado, where he played baseball, basketball, and football.

[2] He made his professional debut that year with the Rookie-level Elizabethton Twins, going 2–1 with two saves and an ERA of 0.57 in nine relief appearances.

[3] Crain was later promoted to the Single-A Quad Cities River Bandits, where he went 1–1 with one save and a 1.50 ERA in nine relief appearances.

[3] In 2004, Crain pitched with the Triple-A Rochester Red Wings and went 3–2 with 19 saves and a 2.49 ERA in 41 relief appearances before being called up by the Twins.

He stepped up, along with Craig Breslow, to fill the eighth-inning setup role formerly occupied by Pat Neshek, who was placed on the 60-day disabled list on May 9 with an acute tear of the ulnar collateral ligament in his throwing arm.

On October 16, the compensation for the White Sox in the trade was named as minor-leaguers Sean Bierman and Ben Kline.

In the 2009 World Baseball Classic, Crain struck out all four batters he faced in the eighth and ninth innings, although Canada ended up losing the game 6 - 2 to Italy.