Jesse Little Thrash (October 21, 1880 – December 12, 1942) was a college football player and engineer.

Thrash was a prominent tackle for the Georgia Tech Yellow Jackets football teams of the Georgia Institute of Technology.

He was inducted into the Georgia Tech Athletics Hall of Fame posthumously in 1962.

[4][5][6] Despite Tech losing every game, he began the season as a sub and closed it as the undisputed star of the Tech team.

His great niece Maria Thrash is a swimming coach, coaching the Tech swimming teams in 2003.