[2] The show features guests such as political commentator Clay Travis,[3] Candace Owens,[4] and Dan Bongino.

[12][better source needed] Jesse Waters Primetime features a design akin to an extreme sports show.

[16] In the wake of the 2020 presidential election, Fox News began a shift in its programming, giving greater prominence to opinion shows.

[19] In the show's debut episode on January 24, Watters garnered an average of 3.8 million viewers, beating out Tucker Carlson Tonight.

[2] By the end of 2022, Jesse Watters Primetime was the third most watched cable news show, behind Tucker Carlson Tonight and The Five, according to Adweek.

[21] Carlson's departure resulted in a downturn in the network's ratings as the timeslot was filled by a rotation of personalities under the Fox News Tonight branding.

This was the program's first episode since the attempted assassination of Donald Trump, as well as its first day broadcasting at the 2024 Republican National Convention.

Following the Colorado Springs nightclub shooting, Watters claimed that drag shows were designed to change the mainstream opinion of "sex with children", among other sexual activities.

Historian Brooks D. Simpson called Watters' statements "abject desperation"; other figures who criticized him include actress Heather Thomas, senior advisor A. J. Delgado, and author Ellen Hopkins.