Jessica "Judy" McCullough Weis (July 8, 1901 – May 1, 1963) was a two-term Republican member of the United States House of Representatives from Rochester, New York.

In 1921 she married Charles William Weis Jr. of Rochester, who became president of the Stecher Traung Lithographic Company.

As a young woman, Weis worked as a volunteer for the Red Cross, the Junior League, and other charitable organizations.

In 1952 Weis was a member of the caucus that helped Dwight D. Eisenhower select a running mate, an experience she described in an essay she contributed to the book, Politics USA.

When Kenneth Keating vacated his house seat to run for the US Senate, Weis was elected to Congress from New York's the 38th District.