She is known for her roles as Clarice in the horror film Leatherface (2017) and Cressida Cowper in the Netflix period drama Bridgerton (2020–).
This was followed by further appearances in an installment of the Sky Arts anthology Playhouse Presents and episodes of the Channel 4 comedy-drama Babylon, the BBC One medical soap opera Holby City, and the period drama Mr Selfridge, also on ITV.
In addition, Madsen made her professional stage debut in Swimming at the Edinburgh Fringe Festival.
[7] In 2019, she appeared in the films Dark Light as Annie Knox and Rambo: Last Blood as Becky.
[8] Madsen was subsequently cast as Cressida Cowper in the 2020 Netflix period drama Bridgerton, an adaptation of the Regency romance novels by Julia Quinn.