[citation needed] On August 30, 2011, Pegula was granted a wildcard into the main draw of the US Open doubles tournament, where she was paired with Taylor Townsend.

She defeated Shuko Aoyama, Margarita Gasparyan, and Melanie Oudin to reach the main draw, where she beat Alison Van Uytvanck in the first round.

Pegula began the year primarily playing on the ITF Circuit, before cracking inside the top 100 in February for the first time in her career.

She was defeated in the first round of the French Open by eventual champion Ashleigh Barty, before falling in the same stage at Wimbledon to Mihaela Buzărnescu.

Despite failing to win another main-draw match the rest of the season, Pegula finished the year ranked inside the top 100 for the first time, at No.

Facing off against 23-time Grand Slam singles winner Serena Williams for the first time, Pegula lost in straight sets.

She then beat Kirsten Flipkens to advance to the third round of a Grand Slam event for the first time, where she lost to sixth seed and former world No.

7 (her 7th top-ten win for the season) and fourth seed, Elina Svitolina, before losing to former two-time champion Victoria Azarenka.

At the Australian Open, she defeated Anhelina Kalinina, Bernarda Pera, Nuria Párrizas Díaz and fifth seed Maria Sakkari to book her second consecutive quarterfinal at this major.

In Doha, she won her second doubles title (and first at the WTA 1000 level) with Coco Gauff, defeating third seeds Elise Mertens and Veronika Kudermetova in the final.

At the Miami Open, she reached her second WTA 1000 semifinal of her career after two back-to-back retirements, Kalinina in round of 16 and Paula Badosa in the first set of the quarterfinal.

[36] As a top-seeded pair, partnering Erin Routliffe, she won her third doubles title at the Washington Open defeating fourth seeds Caty McNally and Anna Kalinskaya.

[37] Seeded seventh at the Canadian Open, she reached back-to-back semifinals in singles, for the fourth time at the WTA 1000-level in her career and third for the season, defeating defending champion Camila Giorgi[38] and Yulia Putintseva, before losing to Simona Halep.

They defeated Madison Keys / Sania Mirza in the semifinals and Nicole Melichar / Ellen Perez in the final to win their second WTA 1000 title together.

[41] Seeded eighth at the US Open, she reached the fourth round, defeating Viktorija Golubic, Aliaksandra Sasnovich, and qualifier Yuan Yue.

At the Guadalajara Open, she reached her second final at the WTA 1000 level defeating four former Grand Slam champions Elena Rybakina, Bianca Andreescu, and Sloane Stephens in the quarterfinals, and Victoria Azarenka in the semifinals.

At the same tournament, she and partner Gauff surprisingly failed to win a single match and also finished last in the round-robin stage of doubles.

Coming off the heels of her win over Świątek and consistency throughout the 2022 season, Pegula was considered one of the favorites for the Australian Open title.

[49][50] In Dubai, she reached her first WTA 1000 semifinal for the season defeating Viktoriya Tomova, Ana Bogdan and Karolína Muchová by walkover, before losing to eventual champion Krejčíková.

They became the first all-American duo to win the Miami Open doubles title in 22 years, defeating Leylah Fernandez and Taylor Townsend in the final.

At Wimbledon, she reached the quarterfinals and became just the fifth American to do so at all four majors in the last 25 years, after notching a straight-sets fourth-round win over Ukrainian Lesia Tsurenko.

At the beginning of the Asian swing, she reached the final of the WTA 500 Japan Women's Open defeating Maria Sakkari,[64] before losing to Veronika Kudermetova.

[79] At the same tournament in doubles with Desirae Krawczyk, she reached the final, which they lost to the duo Nicole Melichar-Martinez / Ellen Perez in straight sets.

In Indian Wells, she lost her debut match to Anna Blinkova and in doubles, she reached the quarterfinals with her usual partner Gauff.

[84] She defended her title at the Canadian Open in Toronto, defeating Karolína Plíšková, qualifier Ashlyn Krueger, Peyton Stearns, 14th seed Diana Shnaider and Amanda Anisimova in the final.

[85] She reached another WTA 1000 final at the Cincinnati Open with wins over Karolina Muchová, Leylah Fernandez, qualifier Taylor Townsend, and Paula Badosa.

[93][94] Partnering with Asia Muhammad, she was runner-up in the doubles at the Wuhan Open, losing to Anna Danilina and Irina Khromacheva in the final.

[95] At the WTA Finals in November, Pegula was eliminated after losing her first two group matches against Coco Gauff[96] and Barbora Krejčíková.

[98] In 2016, Pegula and her sister Kelly opened a quick-serve restaurant called Healthy Scratch in LECOM Harborcenter, an ice hockey-themed mixed-use development owned by her parents in Buffalo, New York.

[103] Pegula made her World TeamTennis debut in 2020 joining the Orlando Storm at the start of the season, which was played at The Greenbrier.