Jessica Antonella Santacruz Cáceres (born 22 January 1990) is a Paraguayan footballer who plays for Austrian club FC Wacker Innsbruck.
From 2010 to 2014, she has been a member of the Paraguay women's national team.
Santacruz played for Paraguay at senior level in two Copa América Femenina editions (2010 and 2014).
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