She came to the Philippines upon Lichauco's invitation in the 1930s at the age of 18,[6] marrying him on December 29, 1933, at the University of Santo Tomas Chapel.

[7][8][3] Lichauco was one of the founders of the Red Feather Agency, later known as Community Chest, which raises funds for member charities.

[3] From 1963 to 1966, her husband served as Philippine Ambassador to the United Kingdom, Denmark, Norway, and Sweden, appointed by then-President Diosdado Macapagal.

Jessie Lichuaco served as the Ambassador's hostess, representing the Philippines in international organizations and events.

The Ambassador's residence in Palace Green was open to Filipino businesspeople, students, workers, and tourists.