JetSmart's primary base of operations is Arturo Merino Benítez International Airport, servicing Santiago, Chile.

It also owns and manages JetSmart Argentina, an Argentine subsidiary with a base at Aeroparque Jorge Newbery in Buenos Aires.

Following the acquisition, it was to operate both from Aeroparque Jorge Newbery and El Palomar Airport in the Buenos Aires area.

[citation needed] On 16 June 2022, JetSMART commenced domestic operations in Peru, marking its expansion into a new market.

[citation needed] JetSmart aimed to operate up to 10 aircraft in the 2018 period, and would go on to challenge LATAM Chile and Sky Airline in nearly every market introduced between July and December 2017.