It is operating cargo flights within South America, to Europe and North America from its hubs at Miami International Airport and Arturo Merino Benítez International Airport.

The airline was formed on May 22, 1970, after the cargo and passenger business of LAN-Chile was separated.

In 1998, it was based on the original cargo divisions of LAN-Chile, Ladeco, and Fast Air Carrier.

[1] LAN Cargo was rebranded to LATAM Cargo Chile as part of the merger of its parent LAN Airlines with TAM Linhas Aéreas to form LATAM Airlines Group during 2016.

During the global COVID-19 pandemic, the airline flew numerous additional routes on an ad-hoc basis, especially in May 2020 and after.