Jerome has since starred as a 13 foot tall boy in Boots Riley's miniseries I'm a Virgo (2023) and as wrestler Anthony Robles in the sports biopic film Unstoppable (2024).

[6] His mother suggested he pursue acting when he was in eighth grade, after which he joined the Riverdale Children's Theatre, a local youth theater organization.

[7][8] Shortly after Jerome enrolled as an undergraduate at Ithaca College, he was cast in his first professional acting role in the 2016 independent film Moonlight, as young Kevin.

[10] Director Barry Jenkins said about Jerome, in an interview with the Los Angeles Times, "When you watch Jharrel in that movie, he's not a guy who's been over-rehearsing.

[8] After his audition the series' director, Ava DuVernay, asked him to read the lines for adult Korey Wise, and he was subsequently cast in both roles.

[11] On September 24, 2020, Jerome released his debut single "For Real", featuring Bronx rapper Kemba and produced by duo Take a Daytrip.