He played Jesus in The Passion of the Christ (2004), Tim Ballard in Sound of Freedom (2023), and starred as John Reese on the CBS series Person of Interest (2011–2016).

Jane (1997), Private Witt in The Thin Red Line (1998), Detective John Sullivan in Frequency (2000), Catch in Angel Eyes (2001), and Edmond Dantès in The Count of Monte Cristo (2002).

Jane (1997), he had a breakthrough performance in the 1998 Terrence Malick-directed World War II film The Thin Red Line.

[2] Caviezel was originally cast to play Scott Summers / Cyclops in X-Men (2000), but dropped out because of a scheduling conflict with the film Frequency (2000).

He starred in the mainstream films Pay It Forward (2000), Angel Eyes (2001), The Count of Monte Cristo (2002), and Bobby Jones: Stroke of Genius (2004).

[19] In 2009, Caviezel played French-Iranian journalist Freidoune Sahebjam in The Stoning of Soraya M., a drama set in 1986 Iran about the execution of a young mother.

When asked about how his Catholic faith was affected by this story, he said, "You don't have to go any further than the gospels to figure out what the right thing to do is, whether you should be more concerned helping someone regardless of their religion or where they're from".

[22][23] From 2011 to 2016, Caviezel starred in the CBS drama series Person of Interest as John Reese, a former CIA agent who now works for a mysterious billionaire as a vigilante.

The show received the highest ratings in 15 years for a series pilot and consistently garnered over 10 million weekly viewers.

[24] Caviezel was nominated for the People's Choice Award for Favorite Dramatic TV Actor in 2014[25] and again in 2016[26] for his work on Person of Interest.

Caviezel starred in the 2014 football film When the Game Stands Tall as De La Salle High School coach Bob Ladouceur, whose Concord, California, Spartans prep team had a 151-game winning streak from 1992 to 2003, an American sporting record.

[27] He appeared in the 2013 film Escape Plan, playing a warden who maintains order in the world's most secret and secure prison.

"[37] In 2018, Caviezel signed on to portray Tim Ballard, a DHS Agent and an anti-human-trafficking activist, in the film Sound of Freedom, about the organization Operation Underground Railroad (O.U.R.)

In a 2017 interview, Caviezel talked about the importance of his Catholic faith, the lasting impact that The Passion of the Christ has had on his life, and his special devotion to the Virgin Mary.

[45][46] During the filming of The Passion of the Christ in Italy, he received daily counsel, confession, and Holy Communion from a local Catholic priest, with an interpreter.

[50] Beginning in 2021, Caviezel endorsed elements of the QAnon conspiracy theory,[51][52] first doing so during a remote appearance at the "Health and Freedom Conference"[53][54] at Rhema Bible Training College in Broken Arrow, Oklahoma.

[60] In October of the same year, Caviezel spoke in Las Vegas at the "For God & Country: Patriot Double Down" conference, where he mentioned the need to fight child sex trafficking, Satan and liberal values.

[61] After Sound of Freedom was released in 2023, Caviezel continued to promote QAnon during interviews and media appearances related to the film.