Prior to joining CBS Interactive, Lanzone was the founder and CEO of Clicker.com, a search engine and discovery guide for Internet video and television funded by Bill Gurley of Benchmark Capital, Geoff Yang of Redpoint Ventures, Allen & Company, Qualcomm Ventures, Slingbox founder Blake Krikorian and several others.

[4][5] Lanzone graduated with a bachelor's degree in political science from the University of California, Los Angeles in 1993.

Noted technology reviewer Walt Mossberg praised the new site as being "richer and better organized than typical Google results"[11] and "took greater strides than Google with their user interface",[12] while Chris Sherman of Search Engine Land called Ask.com the "Apple of Search".

[15] During his time leading digital at CBS, Lanzone was best known for driving the development of the company's numerous streaming services,[16] including the 2014 launch of CBS All Access, home to original shows such as Star Trek: Discovery, Star Trek: Picard, The Good Fight and Jordan Peele's reboot of The Twilight Zone.

[21] On September 10, 2021, he was announced as the new CEO of Yahoo, after the company was sold by Verizon to Apollo Global Management.