Listed at 5 feet 10 inches (1.78 m), 169 pounds (77 kg), he batted and threw right-handed, and was born in St. Louis, Missouri.

Pisoni will forever be known among baseball fans and historians as the last player to debut in a St. Louis Browns uniform.

He was signed by the Browns before the 1949 season, but he spent two years in the military during the Korean War before joining St. Louis on September 25, 1953, becoming the last rookie to debut with the Browns before they moved to Baltimore and became the Orioles.

He appeared in all three remaining games, including playing in the Browns closer on September 29.

He went back to the minor leagues and three years later the Orioles traded him to the Kansas City Athletics.