James Huey Walkup (November 3, 1895 – June 12, 1990) was an American Major League Baseball pitcher.

Walkup made two relief appearances for the Detroit Tigers in 1927, finishing with a 0–0 record and a 5.40 ERA.

He batted right-handed and threw left-handed.

Walkup was born in Havana, Arkansas, and died in Duncan, Oklahoma.

This biographical article relating to an American baseball pitcher born in the 1890s is a stub.