Jimmy Shirley (May 31, 1913 – December 3, 1989) was an American jazz and R&B guitarist who recorded from the 1940s to the 1970s.

He was an early exponent of the electric guitar and was one of the first to use the Vibrola vibrato arm in recordings, such as on "Jimmy’s Blues" (1945).

In 1937, he moved to New York City and spent four years with the Clarence Profit Trio.

During the 1940s, he recorded with Clyde Bernhardt, Sid Catlett, Sidney De Paris, Edmond Hall, John Hardee, Coleman Hawkins, Art Hodes, Billie Holiday, James P. Johnson, Pete Johnson, Billy Kyle, and Ram Ramirez.

He recorded or accompanied singers Wynonie Harris, Jimmy Rushing, Screamin' Jay Hawkins, Little Willie John, Rose Murphy and Barbara Lea.