It is north of the Toluca Valley, part of the region consisting of the southern and western slopes of Cerro La Catedral, which has a concentration of speakers of the Otomi language.

Jiquipilco is situated on the transversal volcanic axis that crosses Mexico in an area surrounded by lakes and volcanoes.

A number of colonial era buildings have been preserved such as the ex–haciendas of Mañí, Nixiní, Santa Isabel, Boximo, some of whose structures are in ruins.

It borders the following municipalities; San Bartolo Morelos, Villa del Carbón, Ciudad Nicholás Romero, Temoaya, Ixtlahuaca, and Jocotitlán.

The municipality also has abundant minerals, mostly nonmetallic, such as silica sand and gravel, and stone, obsidian and quartz, which find use in used mostly in construction and road paving.

[1] After the Spaniards subjugated Toluca, Gonzalo de Sandoval, known as the right arm of Hernán Cortés, promised to bring Jiquipilco under Spanish dominion in 15 days; however, he found an area populated by men who preferred to die on the battlefield.