Although some genealogists claimed that he was the son of Edward, King of Portugal[1] and Joana Manuel de Vilhena, great-granddaughter of Juan Manuel, Prince of Villena, Anselmo Braamcamp Freire dismisses such filiation and provides sufficient arguments against it.
[2] João Manuel joined the Carmelites in 1441 to become provincial of the Order in Portugal.
[1] He was made titular Bishop of Tiberias at the same time by Pope Eugene IV.
[1] Finally, in 1459, he was appointed Bishop of Guarda,[1] a town in which he never actually lived.
[3] From a relationship he had with a Justa Rodrigues, he had two sons, who served Alfonso V and John II of Portugal during their reigns:[3] João Manuel (1466-1500), mayor of Santarém, and Nuno Manuel (1469- after 1500), Lord of Salvaterra de Magos.