A resident of Brooklyn for nearly forty years, Simon formerly served as the president of the Boerum Hill Association before being elected to the New York State Assembly.

[2] On October 1, 2020, Simon announced her candidacy for Brooklyn Borough President in front of James Madison High School as a tribute to Ruth Bader Ginsburg.

If she had been elected, she would have been the first woman to hold the office; she finished in second place, behind City Council member Antonio Reynoso.

In the Assembly, she serves as the chair of the Subcommittee on Tuition Assistance Programs.

Simon is married to Bill Harris and resides in Boerum Hill.