Joanna is an unincorporated community and census-designated place (CDP) in Laurens County, South Carolina, United States.

On April 30, 1865, Confederate President Jefferson Davis and his cabinet passed through the town on their flight from Richmond and spent the night at the Lafayette Young house, 5 miles (8 km) to the southwest.

In 1948 the name of the town was again changed, to "Joanna", the name of the wife of a local industrialist.

Interstate 26 passes 3 miles (5 km) northeast of Joanna, accessible from South Carolina Highway 66.

29.4% of all households were made up of individuals, and 17.4% had someone living alone who was 65 years of age or older.