Wattsville is an unincorporated community in Laurens County, South Carolina, United States.

The area is listed as the Wattsville census-designated place (CDP) for statistical purposes.

South Carolina Highway 49 leaves US 221 in Wattsville, leading northeast 29 miles (47 km) to Union.

According to the United States Census Bureau, the CDP has a total area of 2.3 square miles (5.9 km2), all land.

30.2% of all households were made up of individuals, and 12.5% had someone living alone who was 65 years of age or older.