This phenomenon is thus iodine-induced hyperthyroidism, typically presenting in a patient with endemic goiter (due to iodine deficiency), who relocates to an iodine-abundant geographical area.
[citation needed] The hyperthyroidism usually develops over 2 to 12 weeks following iodine administration.
[2] In some ways the Jod-Basedow phenomenon is the opposite of two physiological compensation mechanisms, the Plummer effect and the Wolff–Chaikoff effect, which in normal persons and in persons with thyroid disease, suppress the thyroid hormone after ingestion of large quantities of iodine or iodide.
However, unlike the Plummer and Wolff-Chaikoff effects, the Jod-Basedow effect does not occur in persons with normal thyroid glands, as thyroid hormone synthesis and release in normal persons is controlled by pituitary TSH secretion, which does not allow hyperthyroidism when extra iodine is ingested.
[citation needed] In iodinated contrast administration for medical imaging, monitoring is indicated in people with thyroid disease, such as toxic multinodular goiter, Graves' disease, or Hashimoto's thyroiditis.