[1] MacDonald uses parametric modeling tools of CATIA-based software combined with digital fabrication processes to produce sculptural and geometrically complex forms and environments.

The Bone Wall was supported by the Harvard Graduate School of Design[11] and became one of MacDonald's early well known works.

[2][12] In 2006, MacDonald collaborated with Thinc to design Water Planet, a multi-media aquarium experience at California Academy of Sciences.

[13] ArtDaily reviewed the Water Planet and wrote that "Constructed using new technologies for computer-aided design and fabrication, the complex molded surfaces seemingly flow into one another, inviting touch and creating an immersive, watery setting.

"[14] In its review, the San Francisco Chronicle wrote that "when the lights are dimmed and images of kelp and underwater life are projected onto the cases, viewers get the feeling of being fully submerged.

[6] MacDonald has regularly incorporated his academic research into practice, most notably in his projects, The Bone Wall and Cairo Tower.

"[24] From 2017 to 2021, Joe MacDonald served on the Weitzman School of Design's faculty at University of Pennsylvania, offering the final 700-series travel studio, to Dubai, Stockholm, Copenhagen and Oslo.

[25][26] His focus in studio aligns with his research-based practice, net-zero and carbon neutral design solutions.