[10] Milton started the first three games but steadily lost more playing time to Cade McNamara as the season progressed.

[13] During the Volunteers' second game of the season against Pittsburgh, Milton suffered an injury, and Hendon Hooker, a fellow transfer quarterback from Virginia Tech, replaced him in the lineup.

[18] On November 19, against South Carolina, Hooker sustained a season-ending ACL injury, making Milton the starter for the rest of the season.

[27] Following conference victories over South Carolina and Texas A&M, Milton had 271 yards and two passing touchdowns in a loss to Alabama.

[38] Milton was named the third-string quarterback behind Jacoby Brissett and fellow rookie Drake Maye to start the 2024 season.

On January 5, 2025, Milton made his professional debut in the season finale against the Buffalo Bills after relieving Maye, who departed after the opening drive.

Milton finished 22-of-29 for 241 yards and accounted for two touchdowns as the Patriots won 23–16, knocking them out of contention for the first overall pick in the 2025 NFL draft.

[39] Milton's cousin, Anquan Boldin, played in the NFL from 2003 to 2016, and won Super Bowl XLVII with the Baltimore Ravens.