[1][2] The series followed entertainer and stand-up comedian Joe Rogan,[3] as well as co-host Duncan Trussell, as they investigated claims about paranormal and mysterious subjects like Bigfoot, psychic ability and UFOs.

The show's form was based on a presentation of the topic following up with interviews with experts and members of the public that claimed anecdotal evidence for the cases.

[9] In the episode "RoboSapien" Joe Rogan interviews Ray Kurzweil with comedian Duncan Trussell appearing as a co-host.

[9] The show was loosely based on conversations and topics from the Joe Rogan Experience, with some video out-takes.

[11][12] Joe Rogan Questions Everything was SyFy's most watched reality premiere in more than five months, averaging 1.3 million total viewers.