Wetshotsile Joseph Seremane (born 26 August 1938) is a former South African politician and federal chairperson of the country's main opposition party, the Democratic Alliance (DA).

Seremane started his career as a school teacher in Bekkersdal in the Gauteng province of South Africa, until he was barred from teaching due to his involvement in politics.

He was a political prisoner on Robben Island from 1963 to 1969, before being deported by the apartheid government to the then black homeland of Bophuthatswana.

He was the Director of Justice and Reconciliation for the South African Council of Churches, and Chief Land Claims Commissioner after the 1994 advent of democracy in the country.

Seremane was the DA's candidate for president in the parliamentary 25 September 2008 vote to elect a successor to Thabo Mbeki.