He was eventually overtaken by Jack Rowley as the club's top goalscorer on 8 March 1952, while his appearances record stood until 11 November 1964, when he was surpassed by Bill Foulkes.
One of United's few true stars between the wars, Spence's wing play made "Give it to Joe" the most commonly heard terrace chant during his 14 years at Old Trafford.
It was his misfortune to be at Old Trafford during some of the most difficult years of the club's history, but in a period when United teams often failed to produce the goods, his entertaining presence was a true highlight.
When the Second World War ended in 1945, newly appointed manager Matt Busby brought Spence back to Manchester United in a coaching and scouting role.
Despite his success at club level player, he was capped only twice by England, his chances of regular international recognition not helped by the fact that he spent several seasons playing outside the top flight.