Johann Baptista Ruffini (1672 – 16 June 1749) was an important salt trader in Bavaria.
He married Maria Johann Unertl (1689–1768), a sister of the Privy Council Chancellor and Conference Minister Franz Xaver Josef Freiherr von Unertl and niece of the Traunstein salt administrative officer Johann Zacharias von Mezger, Edler von Meggenhoven.
His son-in-law was Lieutenant Field Marshal, War Council Director, and Privy Councillor Jean-Gaspard Reichsgraf Basselet von La Rosée.
His grandson was the President of the Electoral Bavarian Upper Court of Appellation, Aloys Reichsgraf Basselet von La Rosée.
The present-day head of the family, Enno Freiherr von Ruffin, has been married to Greek singer Vicky Leandros.