Gottlieb was born on 25 April 1699 in Klosterhäseler, Saxony-Anhalt, the son of Pastor Johann Georg Siegel (1692-1728) and his wife Amanda Helen Elizabeth, daughter of Johann Gottfried Schuchardt, the Auditor of the dragoons .
In 1717, he moved to the University of Leipzig where he attended lectures by Gottfried Polycarp Müller (1685-1747), Lueder Mencke (1658-1726), Johann Christoph Schacher (1667-1720) and Karl Otto Rechenberg (1689-1751).
The teachers at that time included Karl Jakob Spener (1684-1730), Johannes Balthasar Wernher, Heinrich Christoph Berger, Christian Basti Gebhard Neller, Gottfried Ludwig Mencke the Elder and Michael Heinrich Gribner[1] In Wittenberg, on 29 June 1719 he acquired the Licentiate of the rights, and on 26 August 1720 he graduated as a Doctor of Law.
He was general counsel of the University in 1741 and in the winter semester 1753/54 he was president of the Alma Mater.
Siegel married Anna Catharina, daughter of physician Jakob Schmidt, on 19 May 1722 in Klosterhäseler.