He received his first art lessons from his uncle Johann Heinrich Tischbein, sometimes called The Elder to distinguish them.
After spending some time in the Netherlands, he settled in Kassel, where his uncle had established an art gallery for William VIII, Landgrave of Hesse-Kassel.
After 1801, he took custody of his late sister Johanna's son, Franz Pforr, seeing to his education and gaining him admission to the Academy of Fine Arts, Vienna.
His work included portraits; notably one of the poet, Gottfried August Bürger (1771), as well as landscapes and animal paintings.
One of his best-known etchings is that of the so-called "Goethe-Elefant [de]", a popular Indian elephant in the Landgrave's menagerie whose skull was examined and sketched by Goethe following its untimely accidental death from a fall.