John Alexander Henderson (December 21, 1841 – August 10, 1904) was a corporate lawyer and politician in Florida.

He was an early resident of Tampa, the brother of William Benton Henderson.

[4] He served as general consul for the Florida Central & Peninsular Railroad Company.

[5] He was a trustee of the West Florida Seminary, and his daughter Jennie married Albert A.

William D. Bloxham appointed him a US Senator when Wilkinson Call's term expired.