John Augustine Smith (29 August 1782 – 9 February 1865) was an American physician and the tenth president of the College of William & Mary, serving from 1814 to 1826.

He graduated from the College of William & Mary in 1800, then traveled to New York City, where he studied medicine.

In 1809 he became lecturer on anatomy at the College of Physicians and Surgeons, and editor of the Medical and Physiological Journal.

[1][2] In 1824, facing low enrollment at the College, Smith proposed that it be moved to Richmond from Williamsburg;[3] however, the General Assembly refused to authorize the move and the controversy eventually caused Smith to resign.

After leaving William & Mary, Smith returned to New York City and joined the faculty of the College of Physicians and Surgeons, eventually becoming its president in 1831.