John B. Reilly (May 18, 1870 – November 15, 1928) was an American politician who served as the first Mayor of Miami.

He moved to Florida in 1893 accepting the position of bookkeeper and cashier for the firm of McQuire & McDonald, who contracted with Henry M. Flagler and built his hotels.

The city was incorporated shortly after his arrival and due to his key role with the Florida East Coast Railway he was elected mayor in 1896 serving four consecutive 1 year terms.

[3] Reilly served as United States Commissioner for the southern district of Florida being appointed in 1897.

In March, 1914, he became associated with the developments of James Deering's Summer House Villa Vizcaya and acted as financial agent until 1921.