[citation needed] He subsequently appeared in seasons 3 and 4 of the E4 teen drama Skins and the Ken Loach film Route Irish.

[9] He later became a medical representative for the pharmaceutical company Syntex, where he worked until leaving in 2006 to pursue his comedy career full-time at the age of 40.

His material is drawn from his life's experiences, including fatherhood, cycling around the world, playing semi-professional football, and working as a nightclub doorman.

On 12 February 2010, during an appearance on Friday Night with Jonathan Ross it was revealed that prior to his TV breakthrough, Bishop had worked as a warm-up for the show.

In March 2011, Bishop and fellow comedians Alan Carr, James Corden, Catherine Tate, and David Walliams appeared in the video for Take That's single "Happy Now" for Comic Relief.

Before the gig, a reporter called Brian Boyd interviewed him about his recently replenished marriage and how his wife eventually found him funny again.

[7] In November 2013, he hosted the 2013 Royal Variety Performance at the London Palladium theatre in the presence of Charles, Prince of Wales and Camilla, Duchess of Cornwall.

[23] In August 2019, Bishop began presenting a football programme called Back of the Net for Amazon Prime Video with Peter Crouch and Gabby Logan.

[27] On 28 January, it was announced that Bishop would appear as a contestant on the 4th series of The Great Stand Up to Cancer Bake Off in the spring of that year.

[28] In December 2022, Bishop starred as Vic in the pantomime Mother Goose opposite Ian McKellen in the title role at the Duke of York's Theatre in London's West End before touring the UK and Ireland until April 2023.

He drove the Kia Cee'd around the test track in 1 minute and 42.8 seconds to become the fastest star in the latest reasonably priced car, knocking Tom Cruise off the top.

Bishop's record lasted nearly half a year until being knocked off by Rowan Atkinson (1 minute 42.2 seconds) on Sunday 17 July 2011.

[33][34] On 30 March 2010, Bishop took part in Channel 4's Comedy Gala, a benefit show held in aid of Great Ormond Street Hospital, filmed live at the O2 Arena in London.

In 2012, Bishop completed a 290-mile (470 km) triathlon from Paris to London in five days to raise money for the BBC charity Sport Relief.

[35] Also in 2012, he took part in The Justice Collective for their cover of The Hollies single "He Ain't Heavy, He's My Brother" for charities in aid of Hillsborough disaster victims.

On 8 June 2014, he took part in his second Soccer Aid football match, again playing for England, this time losing 4–2 to the Rest of the World.

In 2020, Bishop donated 100 laptops to his former school, Brookvale Academy, as he warned of a "gulf" in society risks leaving children behind.

[36] Bishop competed in the Ciaran Geddes memorial match at the Deva Stadium, scoring two goals while playing with his brother Eddie for Chester.

[41][42] Bishop enjoys playing football and is a Liverpool FC fan, a fact frequently brought up on the show A League of Their Own, on which he was a panellist.