Appointed organist of Westminster Abbey in late 1668,[1] his pupils included William Croft, Jeremiah Clarke and Henry Purcell.

The parish registers at Newark record the baptisms of Blow and of his brother and sister, the marriage of his parents, and the burial of his father.

Blow composed several anthems at an unusually early age, including Lord, Thou hast been our refuge, Lord, rebuke me not and the so-called "club anthem", I will always give thanks, the last in collaboration with Pelham Humfrey and William Turner, either in honour of a victory over the Dutch in 1665, or more probably simply to commemorate the friendly intercourse of the three choristers.

[2] He composed a two-part setting of Robert Herrick's "Goe, perjur'd man", written at the request of Charles II to imitate Giacomo Carissimi's "Dite, o cieli".

[3][2] Blow wrote fourteen services and 30 odes for royal celebrations, 50 secular song-like pieces and more than a hundred anthems.

[2] In addition to purely ecclesiastical music and his relatively well-known masque Venus and Adonis, Blow's works include Great sir, the joy of all our hearts, an ode for New Year's Day 1682, similar compositions for 1683, 1686, 1687, 1688, 1689, 1693 (?

), 1694 and 1700; odes, and the like, for the celebration of St Cecilia's Day for 1684, 1691, 1695 and 1700; for the coronation of James II, two anthems, Behold, O God, our Defender and God spake sometime in visions; some harpsichord pieces for the second part of Henry Playford's Musick's handmaid (1689); Epicedium for Queen Mary (1695) and Ode on the Death of Purcell (1696).