Born in London in March 1780, Chambers began a career in the office of an architect.
[1] On 29 September 1814 he married Mary, the daughter of Peter Le Neve Foster of Wymondham in Norfolk.
He moved to his wife's home at Wymondham, and after about two years, settled at Norwich, so that his sons could attend the grammar school there.
[1] Chambers was the author of the following works:[1] Chambers wrote a Life of Inigo Jones for Arnold's Magazine of the Fine Arts, and contributed to the Gentleman's Magazine, and other periodicals.
The elder son was John Charles Chambers, vicar of St. Mary's and warden of the House of Charity, Soho, from 1856 until his death in 1874; the younger son, Oswald Lyttleton, became in 1863 vicar of Hook, Yorkshire, where he died in 1883.