Born at Roxburgh, Clark studied divinity at the University of Edinburgh, before turning to medicine.
[1] At the end of his life, he was attacked by Thomas Trotter, in the Medical and Physical Journal, over his treatment of a pregnant patient in 1804.
[3] Clark commented, in its first annual report of 1777, that the founding of the Newcastle Dispensary "has as its object the cure of Fevers".
[4] He published:[1] He wrote also an Account of a Plan for Newcastle Infirmary, and papers on institutions for infectious diseases in populous towns.
They had a family of nine children, including William Clark (1788–1869) who became Professor of Anatomy at Cambridge.