A brief appearance at the Strand Theatre under Allcroft's management as Master Toby in ‘Civilisation,’ a play by Wilkins, was followed by a representation, 7 October 1852, at Drury Lane of Fathom in the ‘Hunchback.’ A speculative season, to which he owed this engagement, soon came to an end, and Clarke returned to the country.
His first distinct success was won in burlesque, a line in which his reputation dated from his performance, September 1856, of Ikey the Jew in Leicester Buckingham's travesty of ‘Belphegor.’ At Christmas 1857 Clarke was engaged for the pantomime at Drury Lane, then under the management of E. T. Smith.
He returned, 1858, to the Strand, which had passed into the hands of Miss Swanborough, and played with success in a series of well-remembered burlesques by F. Talfourd, H. J. Byron, and other authors.
Clarke then played with Webster at the Adelphi, at the Olympic, where his Quilp obtained much approval, at the Globe, and in pantomime at Covent Garden.
On 15 April 1865 he took part in the performance of the company headed by Miss Marie Wilton (now Mrs. Bancroft), with which the little theatre in Tottenham Street, Tottenham Court Road, reopened as the Prince of Wales's, and played Amina in Byron's burlesque of ‘La Sonnambula.’ His last appearance was at the Criterion, where he appeared in some new pieces, and in the ‘Porter's Knot.’ In 1873, he married Miss Teresa Furtado, a well-known actress, who died 9 August 1877.