John Willoughby Cole, 2nd Earl of Enniskillen KP (23 March 1768 – 31 March 1840), styled Viscount Cole from 1789 to 1803, was an Irish peer and Member of Parliament.

Both times, he chose to sit for the latter and represented the constituency in the Irish House of Commons until the Act of Union in 1801.

After the Union, Cole was subsequently returned to the British House of Commons for Fermanagh, a seat he held until he succeeded his father to the earldom in 1803.

He was also Governor of Fermanagh until 1831 and thereafter Lord Lieutenant of the county until his death.

They had five children: He died in March 1840, aged 72, and was succeeded in his titles by his eldest son William.