Erne was the eldest surviving son of Abraham Creighton, 1st Baron Erne, and Elizabeth Rogerson, and succeeded his father as second Baron in 1772.
In 1781 he was created Viscount Erne, of Crom Castle in the County of Fermanagh, and in 1789 he was further honoured when he was made Earl Erne, of Crom Castle in the County of Fermanagh.
He sat from 1800 to 1828 as one of the 28 original Irish representative peer in the House of Lords.
[2] He died in September 1828 and was succeeded in his titles by his eldest son Abraham, who had been declared insane since 1798.
His daughter by his second wife, Elizabeth, married the 1st Baron Wharncliffe.