Coincidentally, John Doe is also the name of a television series in which Dominic Purcell (who plays Lincoln Burrows) was the title character.
C-Note (Rockmond Dunbar) is at a campground with his RV and his daughter Dede (Helena Klevorn) in Mound City, Nebraska.
T-Bag tells Susan that he believes that when she spit at him in Fox River State Penitentiary, it proves that she still has strong feelings for him.
Former Captain of the prison guards Brad Bellick (Wade Williams), now an inmate, is standing in a Fox River recreation yard.
He draws the attention of a robust African-American inmate named Banks (Lester "Rasta" Speight) who coerces him to give him his dessert during mealtime in exchange for protection.
Bellick replies that he has candy in his pocket; he brandishes a shlock (a sock filled with batteries, used in prison fights) and bludgeons Banks repeatedly.
A corrections officer covering the perimeter of the Albuquerque, New Mexico tunnel that the escaped brothers vanished from responds to a ringing mobile phone, only to find the body of FBI Agent Alexander Mahone (William Fichtner).
Mahone informs Kim and the agent who killed Veronica that he will no longer work for The Company, even if it means doing his time for the death of Oscar Shales.
Moments later, Mahone receives a frantic telephone call from his wife Pam (Callie Thorne), that their son Cameron had just been hit by a car.
Michael Scofield (Wentworth Miller) and Lincoln Burrows (Dominic Purcell) ride in a black SUV with Kellerman.
A senior police officer appears and instructs them to let Kellerman, busy dialing on his mobile phone, pass unscathed.
Bill Kim's underling discovers that Kellerman and the brothers are en route to Terrence Steadman, and tries to stop their plane from taking off.
Kellerman further informs the brothers that Steadman is just a John Doe; his fingerprints were burned off, his teeth were removed, and he even had plastic surgery to alter key physical features.
Unwilling to cooperate with Kellerman much less trust him, Michael takes the telephone, asks for a television news channel, and informs them of his identity and that he would like to turn himself in.
Unable to cope with the deaths of so many people including his beloved Veronica Donovan, Lincoln angrily points a gun at Steadman's face.
The blood spattered painting and walls of the motel room were soon illuminated by the multicolored lights of police squad cars, as the sirens began to sound.
Marshall Allman (who plays L. J. Burrows), who has been listed as a regular cast member from the series pilot, was removed from the opening credits.
The critics mainly focused on the death of the character Terrence Steadman, who was the most important piece of evidence in proving the innocence of the protagonist Lincoln Burrows prior to this episode.
"[4] On the other hand, iFMagazine's Peter Brown remarked that, "It's obvious the series is taking another turn from them running from the law to proving that there is something going on other than just convicts escaping.
"[5] Also, Bill Harris of the Toronto Sun commented that, "First up comes Prison Break, and we have to say, our heart almost jumped out of our chest at least three times when watching tonight's new episode, titled "John Doe".