The fourth season of Prison Break, an American serial drama television series commenced airing in the United States on September 1, 2008, on Fox.

[1] The fourth season was announced as the final season of Prison Break, however the series returned in a limited series format as Prison Break: Resurrection, which premiered on April 4, 2017.

On January 13, 2009, Fox president Kevin Reilly confirmed the series would end at the conclusion of this season.

He explained, "Prison Break got to a point where a lot of the stories had been told."

At the time, he said there was a possibility of adding two extra episodes, he said "We want to finish strong.