John Wayne Ennis (born October 17, 1979) is an American former professional baseball right-handed relief pitcher.

Ennis made his Major League Baseball (MLB) debut on April 10, 2002, with the Atlanta Braves.

Ennis made his Philadelphia Phillies debut on August 26, 2007, pitching three innings and getting his first career save.

On August 6, 2008, Ennis' contract was sold to the Samsung Lions of the Korea Baseball Organization (KBO), where he pitched for the rest of the season.

This biographical article relating to an American baseball pitcher born in the 1970s is a stub.