John Frederick MacGregor (born 1943 in Ontario, Canada) is a statistician whose work in the field of statistical process control has received significant recognition.

His pioneering work was in the area of latent variable/multivariate analysis (MVA) methods (principal components analysis and partial least squares) applied to industrial processes.

The Canadian Journal of Chemical Engineering dedicated the October 2008 edition to MacGregor in celebration of his 65th birthday.

He is a cofounder of the McMaster Advanced Control Consortium that is sponsored by many international companies.

In 2002, MacGregor established ProSensus Inc., a company that he spun off from the McMaster Advanced Control Consortium and incorporated in 2004.